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Exon 2 was modified to encode 5 amino acid substitutions: T232D, K251A, K254S, K255A, K256A. This also creates an additional NheI restriction site. A floxed neomycin selection cassette was inserted in intron 1. The floxed neo was subsequently excised by crossing to Tg(CMV-cre)1Cgn. Western blot analysis indicates that expression is somewhat reduced and the protein is somewhat insensitive to RAS. (J:147259)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
