A loxP site was inserted upstream of exon 4 and an frt flanked neo cassette and a second loxP site were inserted downstream of exon 4 via homologous recombination. The frt flanked neo cassette was then removed by Flp mediated recombination. (J:147182)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count