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Most of exon 2, all of intron 2 and 102 bp of exon 3, encoding for amino acids 11-132, were deleted in an ES cell line that carried Rxratm1Ipc . A floxed hygro cassette (between exons 2 and 4) and a floxed neo cassette (between exons 9 and 10) were removed by Cre mediated recombination. The final mutant allele lacks both transcriptional activating function 1 and 2. Northern and Western blot analysis confirmed the expression of a truncated mRNA and protein in homozygous and heterozygous embryos. Expression levels of both the truncated mRNA and protein are lower than those for the wild-type mRNA and protein. (J:146761)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
