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In mice with this transgene, the E. coli beta-galactosidase (lacZ) coding sequence is expressed from a minimal promoter under control of a tetrameric repeat of the bone morphogenic protein (BMP) responsive enhancer (BMPRE), a 52 base pair sequence that is located between nucleotides -3523 and -3471 upstream of the mouse homeobox, msh-like 2 (Msx2) gene and comprises the "core element" required for BMP responsiveness. Beta-galactosidase activity in transgenic embryos partially recapitulates the spatiotemporal expression pattern of endogenous Msx2. (J:93586)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
