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Part of exon 3 was replaced with a modified version of a yellow fluorescent protein gene (Venus) and a floxed pgk-neo cassette was inserted in intron 3 via homologous recombination. The neo cassette was then removed by Cre mediated recombination. RT-PCR and autoradiogram analysis confirmed the absence of RNA expression and binding activity in brains from homozygous mice. (J:146587)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
