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Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of glutamic acid, aspartic acid, and glutamic acid for the three arginines at positions 109 to 111. These arginines are necessary for DNA binding activity. An frt flanked neo cassette inserted downstream of exon 1 was removed by germ line, flp mediated recombination. (J:146638)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
