The gene trap vector, which contains a beta-geo cassette, inserted downstream of exon 5. The fusion product lacks the terminal 46 animo acids required to form the active heterodimer. The absence of endogenous protein expression but expression of the lacZ fusion transcript was confirmed by western blot analysis on mouse embryonic fibroblasts and a variety of tissues, respectively. (J:146618)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
Insertion of gene trap vector
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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