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An inversely oriented FRT-flanked neomycin cassette replaced 1.7 kb of the 5' sgamma1 switch region that is upstream of the IgG1 constant region and includes sites of DNA modification and a splice donor site. After targeting 129P2/OlaHsd ES cells, the neomycin cassette was removed by transient expression of Flpe recombinase. Inactivation of the IgG1 switch region was confirmed in (C57BL/6 x 129P2/OlaHsd)F1 mice by a lack of IgG1 with the "a" 129 haplotype (i.e. IgG1a). (J:146428)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
