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The human BAC clone RP11-1376P16 containing the CSNK1D gene was targeted to generate a threonine-to-alanine mutation at amino acid 44 in the protein (T44A). An IRES-GFP cassette was also inserted after the stop codon of the CSNK1D gene. Six lines were generated with 4 of the lines 498, 503, 816 and 830, being low expressers due to insertion of only one copy of the transgene. Transgene expression was confirmed by RT-PCR of brain lysates. This is a representative record for the four low expressing lines. (J:97658)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
