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A cre recombinase gene was inserted into the ATG start site of a murine Pvalb gene located on a BAC. The targeted BAC was inserted into zygotes and four founder lines were generated. This line was chosen for further propagation based on colocalization of cre recombinase and endogenous Pvalb. Cre expression was detected in select neurons of the neocortex, cingurate cortex, pyriform cortex, hippocampus, basal ganglia, and the reticular thalamic nucleus region of the brain. (J:146140)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
