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A 120 bp deletion of nucleotides 573-692 of the gene transcript was created in exon 2. This removes the 40 c-terminal amino acids. A floxed PGK-neomycin cassette was intruduced further downstream. The neomycin cassette was later removed by mating to transgenic Tg(CMV-cre)1Cgn mice. Immunological examination of protein extracts from liver confirmed that a truncated protein was expressed. (J:145513)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
