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Transgenic mice were created using a 270 kb YAC (CEPH clone 366H2) bearing a genomic DNA segment from human Chromosome 6 containing the lipoprotein, Lp(a)-like 2 gene; a 110 kb variant of the gene encoding lipoprotein, Lp(a); and the plasminogen gene. The LPA allele was determined to have 12 tandem copies of the variable copy number, 5.5 kb kringle IV-like repeat. Transgenic mice were shown by northern blot and RT-PCR analysis to express LPA mRNA in the liver and by immunoblot analysis to have significant (up to 75 mg/dL) plasma LPA; expression is suppressed by normal adult male levels of testosterone. (J:144538)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
