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This allele was created by transfer of a male alpha-beta T cell nucleus into an enucleated oocyte. A blastocyte was grown and from this an ES cell clone was derived. The two Tcra alleles in this ES cell were recombined with one a productive, in frame recombination and the other a non-productive, out of frame recombination. Only the productive allele containing a Vbeta1-D1-J1.4 recombination was propagated and is the one described here. Recombination was determined by Southern blotting and inverted PCR. (J:143006)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
