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The tetracyclin operator was used to drive expression of the human cDNA with a point mutation that results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Three lines were generated (13, 121 and 3011). Line 13 carries around 20 copies of the transgene compared to around 60 in line 121. (J:142254)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
