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A floxed neomycin cassette was inserted upstream of the last exon, part of which was replaced with corresponding mouse cDNA sequences containing Ser-Ala mutations in the codons for the first four protein kinase A sites (S789A, S805A, S817A and S848A). The neomycin was left in place because of the increased lethality of heterozygotes that occured when it was removed. (J:145182)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
