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The transgene contains a full length mouse cardiac phospholamban cDNA with two consecutive point mutations (AAT->GCT) that encodes alanine instead of asparagine at amino acid position 27 of the protein (N27A), followed by an SV40 polyadenylation signal, under control of the cardiac-specific alpha myosin heavy chain (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter. Quantitative immunoblot analysis demonstrated cardiac expression of phospholamban protein in this line (91) at 140 +/- 12% the level observed in wild-type hearts. (J:144921)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
