Tg(Cd4-NPM/ALK)N1Ingh

A construct expressing the full-length cDNA of a human NPM-ALK chimeric fusion gene was placed under the control of the murine CD4 promoter. The transgenic cassette (CD4 cassette) included the minimal CD4 enhancer (339 base pair [bp]), the minimal murine CD4 promoter (487 bp), the transcription initiation site, and 70 bp of the untranslated first exon and part of the first intron of the murine CD4 gene, but lacked the CD8 silencer. The fusion gene is expressed in T lymphocytes. Transgenic founder line N1 is representative of two additional lines studied, N14 and N16. (J:82127)