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A human neurotrypsin cDNA was subcloned into the XhoI site of the murine Thy1.2 genomic expression cassette. A loxP-flanked transcription termination cassette was inserted between the Thy1 promoter and the translational start codon of neurotrypsin. Mice carrying this transgene were mated with constitutively expressing Cre mice to delete the floxed transcription termination cassette and activate the dormant transgene. (J:136579)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
