A loxP site was inserted in intron 10 and an frt flanked neomycin selection as well as a second loxP site were placed in intron 14. The neomycin cassette was subsequently removed by crossing to FLPe transgenic mice which leaves exons 11-14 flanked by loxP. (J:144604)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count