Lck^m1Btlr

This mutation was discovered in an in vivo screen of G3 progeny of an ENU mutagenized male mouse for natural killer cell and CD8+ cytotoxicity. It comprises a T to C transition at nucleotide position 1086 (Genbank Accession NM_010693), in the eighth of the gene's 12 exons, resulting in replacement of leucine by proline at amino acid position 300 of the protein (L300P). (J:144695)