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This mutation was discovered in a TLR Signaling Screen of G3 progeny of an ENU mutagenized male mouse. The mutation comprises a T to C transition at nucleotide position 1454 of the gene (Genbank: NM_011604) that results in replacement of isoleucine by threonine at amino acid position 441 of the protein (I441T). (J:144168)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
