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The transgene comprises 6.8 kb of human genomic DNA containing the 5' regulatory sequence of the human opsin 1 (cone pigments), long-wave-sensitive (red cone photoreceptor pigment) gene joined to the coding sequence for enhanced green fluorescent protein followed by a Myc epitope tag and an intron and polyadenylation signal from SV40. Transgenic mice exhibit green fluorescence specifically of cone cells of the visual retina. In this transgenic line, EGFP-expressing cells reproducibly constitute a small proportion of cone cells in the ventral retina and the majority of dorsal retinal cone cells. (J:144387, J:175509)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
