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A loxP-site was inserted upstream of exon 27 in a Hind-III restriction enzyme site, and a loxP site and a Frt-flanked neomycin cassette was inserted downstream of exon 27 at another Hind-III restriction site. The presence of the neomycin resistance cassette generated a null allele as determined by failure to detect full length protein in immunoblot analysis of homozygote brain extracts. (J:144280)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
