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A BAC transgenic mouse was created by using a 155 kb fragment of murine chromosome 14 that had been modified by replacing the start codon of the granzyme B gene with the tamoxifen-dependent recombinase Cre/ERT2 gene. Successful integration of the construct was confirmed through genomic PCR. After crossing to a cre reporter strain and administrating tamoxifen, cre expression was detected in activated CD8 T cells and in NK cells. (J:144174)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
