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A loxP site was inserted upstream of exon 1 and a floxed neomycin cassette was placed downstream of exon 1. Cre recombinase was transiently expressed in correctly targeted ES cells to remove the neomycin selection cassette, leaving exon 1 flanked by loxP sites. Genomic PCR and Southern blotting confirmed removal of the neo cassette and the flox-state of exon 1. (J:95215, J:144110)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
