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A reporter construct was made consisting of an IRES domain, coding sequence for a variant of murine Thy1 (Thy1.1), and a loxP-flanked neomycin cassette. The vector was targeted to exon 3 of the gene locus immediately downstream of the stop codon and within the 3' untranslated portion of the gene. Chimeric founders were bred with B6.EIIa-Cre transgenic mice to remove the neomycin selection cassette. CD4+ T cells isolated from homozygote mice and cultured under Th17 conditions co-expressed both IL-17F and Thy1.1 in a log-linear manner. (J:143729)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
