An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 4 and an additional loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 4 floxed. (J:143988)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count