A loxP site was inserted upstream of the first exon and a Frt-flanked neomycin cassette and a 3' loxP site was inserted downstream of the fourth exon. Correct targeting was confirmed by genomic PCR. (J:143970)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count