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A targeting vector was created by cloning a floxed neomycin resistance gene followed by an IRES-YFP cassette into a BsmBI site located 9 bp downstream of the Igk-C stop codon. This construct was introduced into ES cells containing a Prm1-cre transgene and male chimeric mice were generated. Expression of the cre transgene in male germline cells removed the neo cassette. The Prm1-cre transgene was bred out of the resulting mice. YFP expression was observed in most pre-, immature-, and mature B cells of heterozygote mice. (J:143876)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
