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The rearranged Tcra and Tcrb genes isolated from the CTL clone KB5.C20 of Bl O.BR (H-2kb) origin were isolated. After insertion of the TCR B enhancer between the rearranged VB and CB sequences, the alpha and beta TCR transgene constructs were coinjected. Ten founders were obtained, which had integrated several copies of both transgenes as judged by Southern blot analysis with alpha and beta chain-specific probes. This line, 10395, show a high percentage of thymocytes that express the clonotype. (J:28590, J:134775)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
