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The transgene consists of a purified fragment containing 2.3 kb of the human K14 keratin promoter sequence, 1.1 kb of mouse artemin DNA, and 1.7 kb of the human growth hormone gene containing intron/exon and poly(A) signal sequences. RT-PCR analysis of transgene expression showed a low level of artemin mRNA in skin from WT mice and an enhanced level in skin of ART-OE mice. At the protein level, comparison of artemin immunolabeling of WT and ART-OE skin showed only slight reactivity in the WT epidermis and a significant enhancement in artemin immunoreactivity in transgenic skin that was restricted to the K14 keratin-expressing keratinocytes. (J:111687)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
