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The K14-GDNF transgene contains 2.3 kb of the human K14 keratin promoter sequence, the mouse GDNF cDNA and intron-exon splice sites from the human growth hormone gene. ELISAs were done to measure peptide levels in the skin, DRG, spinal cord, and plasma of adult GDNF-OE and wild-type mice. A sixfold increase of GDNF protein was detected in transgenic skin, whereas in DRG a 4.23-fold increase was measured. Spinal cord levels were also increased by 2.67-fold, suggesting anterograde transport of GDNF from the DRG to the dorsal horn. GDNF was not detected in the plasma of either wild-type or transgenic animals. (J:76684)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
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PMID
Journal
Year
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