A G12D mutation was introduced to the targeted gene along with a reverse orientation lox-stop/puromycin resistance-lox cassette placed in intron 1. The G12D mutant form of protein is conditionally expressed from this gene when a floxed stop segment is excised by Cre. (J:163152)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count