The human gene driven by the CAG promoter was cloned downstream of a floxed neo cassette and 4 polyadenylation sequences (STOP signal). Expression of the human gene can only be achieved by cre-mediated removal of the floxed neo STOP cassette. (J:143278, J:143859)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count