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The gene locus was inactivated by inserting the enhanced green fluorescence protein (GFP) coding sequence in-frame into the ATG-start site of Eki2, replacing part of exon 1 and exon 2. A loxP-flanked neo selection cassette was included downstream of the GFP cassette and was subsequently removed by crossing mice with CMV-cre transgenic mice. Gene inactivation was confirmed by quantitative PCR of testis RNA. GFP expression was observed in the testis of E13.5 embryos and adult males. (J:142456)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
