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A targeting vector was designed to substitute alanine for serine at positions 927 and 933 (S927A, S932A). Targeting took place in PC3 ES cells in which Cre recombinase expression is restricted to haploid spermatids. A loxP-flanked neomycin resistance cassette was included upstream of exon 24 for targeting purposes and was subsequently removed by Cre mediated recombination upon transmission through male chimeric mice. This mutation was predicted to prevent phosphorylation of the gene product by IKK making it resistant to signal-induced degradation. (J:142340)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
