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Depending on the background strain, thymic leukemia antigen (TL) can be encoded by one to three genes. This locus contains the sole gene encoding TL antigen in C57BL/6 mice. Exon 3 of the gene was disrupted by the insertion of a neomycin resistance cassette. Gene inactivation was confirmed in homozygote C57BL/6 mice by a lack of TL antigen detected by flow cytometry on intestinal epithelium. (J:142515)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
