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The promoter was used to drive expression of Ptpn11 containing the amino acid substitution of arginine for glutamine at position 79 in the postnatal heart. This mutation results in an increase in phosphatase activity. Several lines were created and line 197 was used in subsequent experiments. (J:123963)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
