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The ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of arginine for glutamine at position 79, following removal of an intervening floxed chloramphenicol (cat) gene. The amino acid substitution results in an increase in phosphatase activity. Three lines were created and line 1 was used in subsequent experiments. (J:142212)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
