A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette, second loxP site, and a human alkaline phosphatase gene were inserted downstream of exon 3. The neo cassette was then removed by Flp mediated recombination. (J:141834)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count