A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette, second loxP site, and a human alkaline phosphatase gene were inserted in the 3' UTR of exon 3. Quantitative RT-PCR indicated a decrease in RNA expression in homozygous embryos. (J:141834)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion
--
1
7
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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