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A fused human MYC and ESR1 (ERT2) sequence, preceded by a floxed neo cassette with a triple polyadenylation sequence and followed by an IRES-EGFP, was inserted into the ROSA locus. Expression of the fusion product can only be achieved through cre mediated removal of the neo cassette along with its polyadenlylation sequences. Germ line, cre mediated recombination was used to remove the neo cassette and triple polyadenylation sequences to allow for expression of the fusion gene and EGFP. (J:142030)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
