A floxed neo cassette was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. Transient cre expression in ES cells was used to remove the neo cassette leaving exon 3 floxed. (J:141917)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count