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A floxed PGK-hygro cassette was inserted into intron 3 and an additional loxP site was inserted into intron 4. Exon 4 and the selection cassette were removed either by transient cre expression in ES cells or by crossing chimeric mice containing the Smad4 allele to Tg(Sox2-cre)1Amc mice. (J:141589)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
