The serine at amino acid position 38 was mutated to an alanine (S38A) by targeted recombination of exon 2. A loxP-flanked neomycin selection cassette was inserted between exons 2 and 3. Immunoblotting of B cell extracts indicated expression of the mutated protein was similar to that of the endogenous protein. (J:141427)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
Insertion, Nucleotide substitutions
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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