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EN
A retinoic acid response element (RARE) lies about 1-kb upstream from the coding sequence of the gene. The response element was replaced by a floxed neo cassette. Chimeric males bearing the targeted allele were crossed with transgenic mice expressing cre-recombinase to remove the neo-cassette. Whole-mount in situ hybridization revealed reduced expression of the gene locus during embryonic development including in the primitive streak phase and during formation of the neuroectoderm. (J:86514)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
