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The first ATG in the exon 1 was inactivated by insertion of a LacZ-Neomycin cassette at the PstI site. LacZ expression was detected in the cranium, brain, vertebral ganglia, gut, and cardiac cushions of E9.5-E11.5 embryos. Endogenous gene inactivation was confirmed by a lack of signal on Northern blots of RNA extracts from brain and lung of homozygote mice. (J:141063)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
