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This allele contains a loxP-flanked neomycin resistance (neo) cassette inserted into intron 1 and a third loxP site downstream of exon 3. Presence of the neo cassette leads to aberrant splicing and decreased expression levels, making this allele hypomorphic. Cre recombinase excision of only the neo cassette produces Sox9tm1Gsr; excision of both the neo cassette and the floxed segment containing exons 2 and 3 yields Sox9tm1.1Gsr. (J:75124, J:141017)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
