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Exons 2 through 9 were replaced with the human gene (exons 2 through 9 with intronic sequences) with an attB53 site upstream of the human exon 3 and an frt-flanked neo cassette with a 3' attP50 following the human exon 9. ES cells originally used contained Nr1i2tm1(NR1I2)Arte. Germ line, flp mediated recombination was used to remove the neo cassette. The absence of the endogenous transcript expression was confirmed by qPCR on liver and small intestine extracts. (J:140975)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
