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The porcine TGFbeta1 (TGFB1) cDNA containing a double mutation where cysteines at positions 223 and 225 converted to serines is driven by a heptameric tetO sequence and a CMV minimal promoter. The construct also contains a beta-globin intron. Founders were identified by Southern blotting. Mice express the porcine TGFB1 constitutively as a result of the two mutations. TGFB1 expression can be suppressed by crossing this line with a line expressing the tTA transactivator and maintaining pregnant females on a doxycycline-containing water supply. (J:70670)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
